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| First Name: | Igor | | Last Name: | Kurochkin | | Title: | Dr | | Advanced Degrees: | PhD | | Affiliation: | Bioinformatics Institute, A*STAR | | Department: | Genome and Gene Expression Data Analysis Division | | Street Address 1: | 30 Biopolis Street | | Street Address 2: | #07-01 Matrix | | City: | Singapore | | State/Province: | Singapore | | Zip/Postal Code: | 138671 | Country/Territory: | Singapore | | Phone: | (65) 6478 8268 | | Fax: | (65) 6478 9047 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 25 September 2009]
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View all comments by Igor Kurochkin
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Prion Diseases, Polyglutamine Disorders (Huntington's, etc.), Alzheimer Disease, Aging Process
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Bioinformatics/Statistics, Proteomics, A-beta PP/A-beta, Molecular and Cell biology, Protein structure/chemistry, Neurobiology, DNA microarrays, Genetics
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Kurochkin, I. V. and Goto, S. (1994) Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345, 33-37
Kurochkin, I. V. (2001) Insulin degrading enzyme: embarking on amyloid destruction - Opinion. Trends Biochem. Sci. 26, 421-425
Kurochkin, I. V. (1998) Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme. FEBS Lett. 427, 153-156
Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schonbach C, Okazaki Y. (2007) Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. EMBO J. 26, 835-845. Epub 2007 Jan 25.
Morita, M., Kurochkin, I. V., Motojima, K., Goto, S., Takano, T., Okamura, S., Sato, R., Yokota, S. and Imanaka, T. (2000) Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins. Cell Struct. Funct. 25, 309-315
Kurochkin, I. V., Yonemitsu, N., Funahashi, S. and Nomura, H. (2001) ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Biochem. Biophys. Res. Commun. 280, 340-347
Kurochkin, I. V., Procyk, R., Bishop, P. D., Yee, V. C., Teller, D. C., Ingham, K. C. and Medved, L. V. (1995) Domain structure, stability and domain-domain interactions in recombinant factor XIII. J. Mol. Biol. 248, 414-430 |
Amyloid-beta accumulation in Alzheimer's disease is caused by impaired activity of insulin degrading enzyme (IDE). Hence activating, up-regulating IDE would provide means to treat the diaease |
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